Metabolomic Profiling of Fatty Acid and Amino AcidMetabolism in YouthWith Obesity and Type 2 Diabetes Evidence for enhanced mitochondrial oxidation
نویسندگان
چکیده
RESULTSdLong-chain AcylCNs (C18:2-CN to C14:0-CN) were similar among the three groups. Mediumto short-chain AcylCNs (except C8 and C10) were significantly lower in type 2 diabetes compared with NW, andwhen comparedwithOB, C2-, C6and C10-CN, were lower. Amino acid concentrations were lower in type 2 diabetes compared with NW. Fasting lipolysis and FOXwere higher in OB and type 2 diabetes compared with NW, and the negative association of FOX to C10:1 disappeared after controlling for adiposity, Tanner stage, and sex. IS was lower in OB and type 2 diabetes with positive associations between IS and arginine, histidine, and serine after adjusting for adiposity, Tanner stage, and sex.
منابع مشابه
Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth With Obesity and Type 2 Diabetes
OBJECTIVE We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents. RESEARCH DESIGN AND METHODS Fasting plasma was analyzed by tandem mass spectrometry, body composition by dual energy X-ray absorptiometry and computed tomography, and tota...
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